Clear Yellow Solution at 1Mg/Ml in Dimethylsulfoxide
Protect from light and moisture
Store in a cool and dry area. Keep sealed and keep away from direct light.
Safety Information of Camptothecin (cas number:7689-03-4) as below:
UN 1544 6.1/PG 3
1. Camptothecin is the natural starting material of Irinotecan HCl.
2. Camptothecin is the natural starting compound of 10-Hydroxycamptothecin.
3. Camptothecin is the natural starting ingredient of 7-Ethyl-10-Hydroxycamptothecin(SN-38).
4. Camptothecin is the natural starting ingredient of Topotecan HCl
5. This compound camptothecin is a featured product for Apoptosis research.
Packing & Storage
Packing with IATA required carton with 10kg/carton, or as customer required.
Stored in a cool, dry and dark place, shelf life 24 months.
Function: Camptothecin showed remarkable anticancer activity in preliminary clinical trials by inhibiting the DNA enzyme topoisomerase I (topo I). (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
Natural origins of camptothecin:
1. Camptotheca acuminata (Camptotheca, Happy tree), a tree native to Hunan ,Guangxi, Sichuan province of China. Camptotheca acuminata used as a cancer treatment in Traditional Chinese Medicine.Generally, the leaves and the fruits of happy tree are applied for the extraction of camptothecin.
2. Nothapodytes pittosporoides(Mappia), a tree wild spread in Hunan ,Guangxi, Sichuan province of China. The root of the tree is applied for the extraction of campothecin, most of this origin is applied for R&D.
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